曲唑酮治疗老年痴呆伴睡眠障碍患者的有效性及安全性.pdf

临床医学研究与实践 2021 年 6 月第 6 卷第 18 期 临床医学
曲唑酮治疗老年痴呆伴睡眠障碍orders
ZHANGSining,CHENGYao,LIXiaofen,WENLiangliang
(PsychologyDepartment,JiaozuoCityMentalHospital,Jiaozuo454000,China)
ABSTRACT: Objective
Toanalyzetheefficacyandsafetyoftrazodoneinthetreatmentofpatientswithseniledementia
Methods
andsleepdisorders. Atotalof92seniledementiapatientswithsleepdisorderstreatedinourhospitalfrom
(46
cases)andexperimentalgroup(46cases),
-derivedneurotrophicfactor (BDNF),5-
hydroxytryptamine (5-HT)anddopamine (DA)beforeandaftertreatmentwerecomparedbetweenthetwogroups;
Pittsburghsleepqualityindex (PSQI)wasusedtoevaluatethesleepqualityofthetwogroupsbeforeandaftertreatment;
Results
theimprovementeffectofsleepqualityandadversereactionswerecomparedbetweenthetwogroups. After
treatment,thelevelsofBDNF,5-HTandDAinthetwogroupswerehigherthanthosebeforetreatment,andth