克罗恩病概述.pdf

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treatment of CD patients. The disease
is currently increasing in China. The symp tom s of CD are heterogeneous but commonly include abdom inal pain, di
arrhea and weight loss, which are largely dependent on the stages ( early, active, rem itted, and chronic active sta
ges, respectively) of the disease. A single gold standard for the diagnosis of CD is not available. The diagnosis is
confirmed by clinical evaluation and a combination of endoscop ic, histological, radiological, and /or biochem ical in
vestigations. Behavior of the disease varies substantially during its course. About 13% ～20% of patients with CD
have a chronic active course of disease. 67% ～73% have a chronic interm ittent course for several years. After 20
years most patients will need surgery. The life expectancy is slightly reduced.
Keywords:Crohn s disease; natalizumab; Vedolizumab;MadCAM 1
　　郑家驹 ,医学博士 、主任医师 、博士 现 ,症状反复发作与缓解交替 ,迄今尚无彻底治愈本病的方
生导师 。工作于南京大学附属苏州医院 法 ,即使手术切除病变肠段后也可能复发 ,为终身致残性疾
消化内科。兼任中华医学会消化病学分 病 。
　
会炎症性肠病学组副组长 。苏州市消化