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DOI:
New Approach to the Synthesis of N7-Arylguanines and probably due to the low solubility of adenine. This problem
ing hormone receptors[2d–2f] and folic acid receptors[2g] as
was overcome by using CH OH/H O as the solvent[12] or
inhibitors of enzymes like phosphatidylinositol 4-kinase,[2h] 3 2
by the arylation of N6,N6-bis-BOC-adenine, which was then
adenosine[2i] and guanine[2j] deaminase and xanthine ox-
deprotected.[13] Similarly, the direct arylation of guanine,
idase.[2k–2n] Also N9-arylpurines have been reported to exhi-
due to its insolubility in most solvents, has not been re-
bit antimicrobial activity.[2g,2o] Arylguanines may be formed
ported. However, the arylguanines may be prepared indi-
in vivo by the interaction of arene oxides formed by the
rectly by the arylation of N2,N2-bis-BOC-6-chloropurine
metabolic activation of mutagenic and carcinogenic arenes
followed by acid hydrolysis.[13]
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