外文文献87669.pdf

ORIGINAL ARTICLE
plex: An Integrative Approach to
Frontotemporal Dementia
Primary Progressive Aphasia, Corticobasal Degeneration, and
Progressive Supranuclear Palsy
Andrew Kertesz, MD, FRCPC
Key Words: frontotemporal dementia, corticobasal degeneration,
Background: Frontotemporal dementia (FTD) is a new label for
Pick’s disease, plex, primary progressive aphasia,
clinical Pick’s disease (PiD) because the eponymic term is increas-
progressive supranuclear palsy, motor neuron disease, ics,
ingly restricted to the pathologic finding of Pick bodies. This
tau mutation, tauopathies
restriction created the impression that PiD is rare and that it is
difficult to diagnose. FTD is also a term most often used for (The Neurologist 2003;9: 311–317)
behavioral and personality alterations. Primary progressive aphasia
(PPA) and corticobasal degeneration (CBD), formerly the extrapy-
ramidal variety of PiD, are also part of the syndrome. Recently,
chromosome 17 localization and tau mutations were discovered in
familial forms of the disease. rontotemporal dementia (FTD) is ing increasingly
Review Summary: FTD consists of behavioral and personality Frecognized. The original descriptions of Pick included the
changes, often beginning with apathy and disinterest, which may be behavioral presentation of FTD as well as the aphasic variety,
mistaken for depression. Disinhibi