系统性红斑狼疮 systemic lupus erythematosus.ppt

1 1 中国医科大学附属一院风湿免疫科张榕系统性红斑狼疮系统性红斑狼疮(SLE) (SLE) Systemic Lupus Systemic Lupus Erythematosus Erythematosus 2 系统性红斑狼疮 Systemic Lupus Erythematosus Many Different Auto- antibodies Multiple System Involvement 3 系统性红斑狼疮 SLE onset by sex and age 0 10 20 30 40 50 60 70 80 90 Number of patients 10 20 30 40 50 60 70 80 Age Male Female4 系统性红斑狼疮 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 5 系统性红斑狼疮 Etiology ic factors environmental factors Sex hormonal factors 6 系统性红斑狼疮 Pathogenesis Excessive, abnormal production of “ self ” antibodies and formation of IC . Autoantibodies against nuclear, cytoplasmic and ponents of multiple cell types in ans . 7 系统性红斑狼疮 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 8 系统性红斑狼疮 Pathology 光镜:1. 结缔组织的纤维蛋白样变性 :疣状心内膜炎苏木紫小体“洋葱皮样”病变临床应用:皮肤狼疮带试验肾活检 9 系统性红斑狼疮 Etiology and pathogenesis pathology Clinical findings Laboratory findings Diagnosis Treatment prognosis 10 系统性红斑狼疮