·924· 第 37 卷第 5 期 2022 年 5 月 现代药物与临床 Drugs & Clinic Vol. 37 No. 5 May 2022 京万红软膏对糖尿病足大鼠 mechanism of Jingwanhong Ointment on diabetic foot rats. Methods Select 40 healthy rats, divided into control, model, Jingwanhong Ointment, and rhEGF groups, each group had 10 rats. The diabetic foot model was established in all rats except the control group. All rats were given the drug on the 2nd day after modeling, and the area around the foot wound was cleaned with normal saline before the drug was applied. Rats in the model group were applied with normal saline every day, and were routinely fed with rats in the control group. Jingwanhong Ointment group applied 3 g/kg Jingwanhong Ointment every day to cover the wound, rhEGF group was given rhEGF external solution 4 000 U once daily. Rats in each group were continuously given drugs for 15 d. The wound healing was observed by foot images of rats. AGEs, RAGE, and blood glucose levels were determined by ELISA. The pathological expression of HE staining was observed. Western blotting was used to detect the expression of CTGF, ERK, and P-ERK proteins. The mRNA expressions of HMGBA, HMGB1, ERK1 and ERK2 were detected. Results Compared with the model control group, the wound surface of Jingwanhong Ointment group and rhEGF group were reduced after treatment, and the effect of J
