三环类抗抑郁药Tricyclicantidepressants.doc

三环类抗抑郁药(Tricyclic antidepressants)
[overview and classification]
Tricyclic antidepressants (TCA) have been used in thecan be subdivided into tertiary amines such as imiquimod parmin, amitriptyline, doxepin and secondary amine, the latter is more to methyl tertiary amine metabolites such as norepinephrine Amy parmin (desipramine and nortriptyline). Of the fourth class, TCAs, but its pharmacological properties are similar to those of a..
[pharmacological effects]
of the central nervous system of normal oral administration of the drug, appear dizziness, dry mouth, drowsiness, blurred vision and blood pressure drop slightly. If continuous medication for several days, the above symptoms increased, and lack of concentration, thinking ability decreased. In contrast, patients with depression after continuous medication, mood improvement, mental stimulation, there is a significant antidepressant effect. But the slow onset of imipramine, continuous medication for 2 ~ 3 weeks after work, it is not for emergency medicine application.
Used to study the protective effects of anti depressive mechanism, early detection of reserpine can cause depression symptoms, while pretreatment with Mipamingzeke prevent, but if the first with reserpine depletion of brain catecholamine is invalid. That must have imipramine in brain catecholamine storage, can play the role of antidepressant. So we hypoth