唐氏综合征筛查指标MoM值的正态性研究.doc

1 唐氏综合征筛查指标 MoM 值的正态性研究【关键词】唐氏综合征 Normality of MoM of screening indexes for Downs syndrome 【 Abstract 】 AIM: To explore the normality of MoM values of AFP and HCG used to screen the Downs syndrome in Jiangsu province, and discuss the feasibility and effectiveness of application of SL transformation in Johnson system of distributions which is used to normalize MoM values of indexes above. METHODS: The data were obtained from the research project on birth defect intervention in Jiangsu province . SL transformation in lognormal distribution and Johnson distribution system was used to normalize MoM values of AFP and hCG in prenatal screening for Downs syndrome. RESULTS: The MoM values of AFP and HCG were both not of normal distribution. Through the lognormal distribution of MoM values, AFP was in accord with normal distribution and hCG was not. Normality of HCG MoM became better at Z=. CONCLUSION: It is suitable for the indexes of prenatal screening for Downs syndrome in our country to use SL 2 normality transformation in Johnson system of distributions. 【 Keywords 】 Downs syndrome; prenatal screening; normality; Johnson distribution system 【摘要】目的: 考察江苏唐氏综合征产前筛查指标 AFP 和 HCG 的 MoM 值的正态性, 探索 Johnson 分布体系中的 SL 分布族在上述指标正态性转换中应用的可行性和有效性. 方法: 资料来自于江苏省出生缺陷干预项目研究, 采用对数正态和 Johnson 分布体系中的 SL : 两指标的 MoM 值均不服从正态分布;对数 MoMHC G 值以样本均数和标准差作为参数时,指标 AFP 的正态性较好, HCG 仍不服从正态; Z= 时 MoM