结果 两组患者在镇静后心率、平均动脉压、脉搏血氧饱和度均较术前有所下降，至出 PACU 时基本恢复 至术前水平，组间比较显示，试验组心率及平均动脉压整体波动幅度均小于对照组 (P＜)。与对照组 比较，试验组唤醒时间、PACU 停留时间缩短，低血压发生率降低，但体动反应等级和加药次数上升(P＜ )。试验组检查后 24 小时的 NCT-A 和 DST 测试结果与检查前比较差异无统计学意义，与对照组比较 差异亦无统计学意义(P＞)。结论 瑞马唑仑应用于肝硬化患者无痛胃镜检查，对心率和血压影响更小， 且无诱发或加重轻微肝性脑病的风险，具有更高的安全性。 关键词：瑞马唑仑；肝硬化；消化道内镜检查；镇静 中图分类号：R614 Clinical Utility of Remimazolam for Painless Gastroscopy in Patients with Liver Cirrhosis HE Jiang，FU Baojun，YE Yanxia，XIANG Wenyue (Department of Anesthesiology，the Sixth Affiliated Hospital of Guangzhou Medical University， Qingyuan People's Hospital, Qingyuan，Guangdong 511518，China) ABSTRACT: OBJECTIVE To evaluate the efficacy and safety of remimazolam for painless gastroscopy in patients with cirrhosis. METHODS A total of sixty-four cirrhotic patients undergoing gastroscopy, aged 18~64, with American society of Anesthesiologists physical status Ⅱ or Ⅲ, were enrolled in this study a
