最新盐酸吉西他滨降解实验研究.doc

of accountability, redress of orders and prohibitions. Strengthening the honesty and self-discipline of leading cadres h剂.............................................................................................5
〔二〕盐酸吉西他滨HPLC降解实验方法的建立...................................................6
〔三〕盐酸吉西他滨HPLC降解实验的操作步骤...................................................7
〔四〕实验数据的计算与汇总比照.........................................................................10
三、实验的结果和方法可行性的分析.............................................................................12
〔一〕含量及相关物质的系统适应性及专属性分析............................................12
〔二〕各降解条件下的稳定性数据分析................................................................12
四、结论.............................................................................................................................13
五、典型图谱.....................................................................................................................14
六、参考文献.....................................................................................................................16
of accountability, redress of orders and prohibitions. Strengthening the honesty and self-discipline of leading cadres honesty in politics and education work, enhance leaders ability to resist16
of accountability, redress of orders and prohibitions. Strengthening the honesty and self-discipline of leading cadres honesty in politics and education work, enhance leaders ability to resist3
of accountability, redress of orders and prohibitions. Strengthening the honesty and self-discipline of leading cadres honesty in politics and education work, enhance leaders ability to resist
一、文献综述
〔一〕盐酸吉西他滨的化学名和药理作用及药代动力学
盐酸吉西他滨英文名为Gemcitabine Hydrochloride。化学名为：4-氨基-1-(3,3-二氟-4-羟基-5-羟甲基四氢呋喃-2-基)-1H-嘧啶-2-酮盐酸盐。
盐酸吉西他滨作为一种前药在细胞内是脱氧胸苷激酶磷酸化的良好底物，在酶的作用下转化成以下代谢物：吉西他滨一磷酸盐〔dFdCMP〕、吉西他滨二磷酸盐〔dFdCDP〕和吉西他滨三磷酸盐〔dFdCTP〕其中dFdCDP和dFdCTP为活性产物。dFdCDP抑制核