临床医学论文-伊贝沙坦对高血压左室肥厚患者的左室结构的影响 【关键词】 左心室肥厚;伊贝沙坦 伊贝沙坦对高血压左室肥厚患者的左室结构的影响(pdf) [摘要] 目的 研究伊贝沙坦对高血压左室肥厚(LVH)患者的左室结构的影响。 方法 60例原发性高血压左室肥厚患者随机分为2组:治疗组每天口服伊贝沙坦150 mg,对照组每天口服氨氯地平5 mg。平均12个月,观察用药后血压、左室结构的变化。 结果 用药后2组收缩压(SBP)和舒张压(DBP)均显著降低(P<);室间隔厚度(IVST)及左室后壁厚度(LYPWT)均变薄(P<),左室重量指数(LYMI)明显减少(P<),对照组各项指标无明显变化(P<)。 结论 对原发性高血压左室肥厚的患者,长期应用伊贝沙坦具有良好降压效果,同时还可逆转LVH,改善患者预后。 [关键词] 左心室肥厚;伊贝沙坦 Effect of irbesartan on left ventricular structure in patients with hypertensive left ventricular hypertrophy [Abstract] Objective To study the effect of irbesartan on the left ventricular structure in patients with hypertensive left ventricular hypertrophy(LVH). Methods 60 cases of hypertensive LVH were randomly divided into two groups:treatment group who took orally 150 mg irbesartan every day and control group who took orally 5mg amlodipine every day for average time of 12 administration,blood pressure,left ventricular structure were observed. Results After administration,systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the two groups were significantly decreased (P<).In treatment group,the intraventricular septum thickness(IVST) and left ventricular posterior wall thickness (LVPWT) became obviously thin (P<); left ventricular mass index(LVMI) was reduced (P<).However there was no obvi
