多西紫杉醇联合奥沙利铂和5.doc

多西紫杉醇联合奥沙利铂和5
作者:史会昌,周学义,薛玉保
【摘要】目的考察多西紫杉醇联合奥沙利铂、5-氟尿嘧啶和亚叶酸钙方案治疗晚期胃癌的临床效果。方法 33例晚期胃癌患者给予多西紫杉醇35 mg/m2(第1天,第8天,第15天),奥沙利铂85 mg/m2(第1天,第8天),5-氟尿嘧啶500 mg/m2(第1天至第5天),28天为1周期,疗程4周期。结果 33例患者中完全缓解3例,部分缓解16例,稳定10例,进展4例,%;,常见的毒性反应为白细胞和中性粒细胞减低,消化道反应和周围神经毒性反应等。结论多西紫杉醇联合奥沙利铂、5-氟尿嘧啶及亚叶酸钙化疗方案治疗晚期胃癌的疗效显著,毒性反应患者能耐受,可能延长患者生存期。
【关键词】多西紫杉醇;奥沙利铂;5-氟尿嘧啶;晚期胃癌

Abstract: Objective To evaluate the clinical efficacy of the regimen of docetaxel bined folinate in the treatment of advanced gastric cancer. Methods 33 patients g/m2 (day 1, 8 and 15), oxaliplatin 85 mg/m2 (day 1 and 8) and fluorouracil 500 mg/m2 (1~5 d) for 4 cycles, ission, 17 cases had partial remission, 6 cases had stable disease and 6 cases had progressive disease, edian time to progression onth. The most mon adverse reactions included leucopenia, neutronpenia, gastrointestinal tract reactions (nausea, vomit and diarrhea) and peripheral neuropathy, etc. Conclusion The regimen of docetaxel bined folinate in the treatment of advanced gastric cancer has remarkable response rate and tolerable toxicity, ay contribute to the prolonged survival of the patients.

Key g/m2,加入生理盐水250 ml,静脉输注,第1、8、15天。为预防使用多西紫杉醇可能导致的液体潴留综合征,在使用该药治疗前1天,均口服地塞米松8 mg,每日2次,连用3天。5-氟尿嘧啶(南通制药总厂生产,批号:0109043)500 mg每日1次,使用微量输液泵持续静脉输注,连用5天; g。奥沙利铂(艾恒,江苏恒瑞医药生产,批号:H20040817)85 mg/m2加入5%葡萄糖溶液500 ml中输注,第1天、8天给药。以上方案每4周重复,每周