他克莫司治疗狼疮性肾炎的前瞻性.doc

他克莫司治疗狼疮性肾炎的前瞻性
ok3g/(kg·d)]和传统疗法组20例(CTX 1 g/月×6月),同时口服泼尼松1 mg /(kg·d),比较两组治疗3、6个月的临床疗效。疗效评价分为完全缓解(CR),部分缓解(PR)及无效(NR)。【结果】治疗3个月内他克莫司组有3例退出,传统疗法组有4例退出。诱导治疗3个月他克莫司组的总有效率(76%,CR 5/17,PR 8/17)显着高于传统疗法组(%,CR 2/16,PR 4/16,P< )。%( CR 11/17, PR 4/17)%(CR 5/16, PR 5/16)。治疗3个月及6个月,他克莫司组在水肿消退、尿蛋白水平下降、血清白蛋白升高、SLEDAI减少等方面与传统疗法比较,均有显着差异(P< ),而且出现副反应较传统疗法组为少。【结论】与传统疗法相比,他克莫司联合激素是一种快速有效地诱导LN缓解的治疗方法。
【关键词】狼疮肾炎; 他克莫司; 环磷酰胺; 诱导治疗
Abstract:【Objective】 To evaluate the efficacy of tacrolimus as the induction therapy in the patients al renal function and class Ⅲ,Ⅳ,Ⅴ of LN proven by renal biopsy. They are randomly assigned to either tacrolimus mg (/kg·d) for 6 months or intravenous cyclophosphamide (CTX) 1 g monthly for 6 month in addition to corticosteroids. The baseline characteristics betission (CR), partial remission (PR), and no-response (NR). 【Results】 There us group and 4 patients in CTX group that the study for 3 month treatment. The remission rate after 3 months in tacrolimus group (76%,CR 5/17,PR 8/17) ission occurred in 15 out of 17 patients (%,CR 11/17,PR 4/17) in the tacrolimus group and 10 out of 16 patients (%,CR 5/16, PR 5/16) in the CTX group at 6 months. Tacrolimus as induction therapy ore effective in improvement of the edema, proteinuria, serum albumin and SLEDAI, and better tolerated us bined ore effective than