Hindawi Publishing Corporation
Journal of Obesity
Volume 2012, Article ID 147256, 9 pages
doi:
Review Article
Review of Metabolic Surgery for Type 2 Diabetes in
Patients with a BMI < 35 kg/m2
Hideharu Shimizu, Poochong Timratana, Philip R. Schauer, and Tomasz Rogula
M61 Cleveland Clinic, Bariatric and Metabolic Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Correspondence should be addressed to Tomasz Rogula,
Received 5 January 2012; Accepted 30 March 2012
Academic Editor: R. Prager
Copyright © 2012 Hideharu Shimizu et al. This is an open access article distributed under the mons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Bariatric/metabolic surgery is considered an accepted treatment option for type 2 diabetes mellitus (T2DM) with body mass index
(BMI) 35 kg/m2. Mounting evidence also shows that metabolic surgery is effective for T2DM with BMI < 35 kg/
current status of metabolic surgery, we reviewed the available clinical studies which described surgical treatment for T2DM with
mean BMI < 35 kg/m2. 18 studies with 477 patients were identified. 30% of the patients was insulin users. The follow-up period
ranged from 6 to 216 months. The weight loss effect was reasonable, not excessive. Mean BMI decreased from to kg/m2.
Remission of T2DM was achieved in % of the patients with fasting plasma glucose and glycated hemoglobin approaching
slightly above normal range. Clinical T2DM status was an important factor when selecting the eligible candidates for metabolic
surgery. plication rate of % with mortality of 0% in the studies has been acceptable. Even though it would
be premature at this point to state that metabolic surgery is an accepted treatment option for T2DM with BMI < 35 kg/m2,itis
clear that a high proportion of T2DM patients will derive substantial benefit from m
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