吲哚美辛缓释片的制备.doc

吲哚美辛缓释片的制备
本科生毕业论文(设计)
吲哚美辛缓释片的处方研究与制备
姓名: 巴晓静指导教师: 柯仲成院系: 化学化工学院专业: 制药工程提交日期: 2012年3月29日
黄山学院本科毕业论文
目录
中文摘要??????????????????????????????2 外文摘要????????????????????????????3 引言????????????????????????????????4 1 实验部分?????????????????????????????6
仪器与试剂??????????????????????????6
标准曲线的建立????????????????????????7
缓释片的制备???????????????????????7
溶液的配制????????????????????????7
最大吸收波长的选择????????????????????7
标准曲线的绘制??????????????????????7
??????????????????????8
精密度实验????????????????????????9
回收率实验????????????????????????9
吲哚美辛缓释片的处方拟定与制备???????????????10
???????????????????????10
??????????????????????10 2 实验结果分析与小结???????????????????????11
释放过程考察????????????????????????11
???????????????????????12
?????????????????????????13 3 总结??????????????????????????????13 参考文献?????????????????????????????15 致谢???????????????????????????????16
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黄山学院本科毕业论文
吲哚美辛缓释片的处方研究与制备
巴晓静
指导老师:柯仲成
(黄山学院化学化工学院,黄山,安徽 245041)
摘要:本文主要目的是为了改善吲哚美辛普通口服制剂的释药过程,减少毒副作用,提高患者顺应性,将制成吲哚美辛缓释片。以亲水性羟丙甲基纤维素作为骨架材料,采用湿法制粒压片制得,然后通过紫外分光光度计在320nm波长下考察其体外释放度,进行释药机制的研究。最后通过平行试验测定各处方在2h、6h、12h的累积释药量以及对其释药曲线的考察,经过处方筛选,最终优选得到最佳处方。结果表明采用处方
5所制备的缓释片具有良好的缓释效果,而且制备过程操作简单。
关键词:吲哚美辛;缓释骨架片;释放度;处方筛选
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黄山学院本科毕业论文
Preparation and invitro Release of Indomethacin Sustained Release Tablets
Ba Xiaojing
Director:Ke Zhongcheng
(College of Chemistry and Chemical Engineering, Huangshan University,
Huangshan, Anhui, 245041)
Abstract:The main purpose of this paper is to improve oral mon preparation process of drug release, reduce toxicity, the patients pliance, and will be made into Indomethacin Sustained-release tables. The wather-soluble hydrophilic matrix HPMC(K4) was used to prepare sustaind-release tablets by the wet pression technique. The content of the major drug was determined by UV spectrophotometry at 320nm, the release mechanic was studied by dete