痤疮丙酸杆菌.ppt

Propionibacterium acnes-Reactive T Helper-1 Cells in the Skin of Patients with Acne Vulgaris
存在于寻常痤疮患者皮肤中的痤疮丙酸杆菌T助细胞—1
To the Editor: Acne vulgaris is monest skin disorder to affect humans, characterized by both noninfammatory (comedones) and inflammatory lesions (papules, pustules, and nodulocystic lesions). It is a disease of the pilosebaceous follicle edones resulting from thehypercornification of the keratinocytes of the duct wall and usually preceding inflammatory lesions (Cunliffeetal, 2000).
寻常痤疮是最普通的能影响人体健康的皮肤紊乱疾病,既有非发炎性(如粉刺)又有发炎性(如丘疹、脓包、结囊肿损害)损害特点,这是一种毛皮脂腺囊疾病,输送管壁的角蛋白超角质化或上面提到的发炎性损害导致了粉刺的形成(Cunliffe et al,2000)
Of particular interest in the pathophysiology of inflammatory acne is the role of the normal mensal bacterium Propionibacterium acnes. Although not a requirement edogenesis, a number of observations have suggested that is implicated in the pathogenesis of inflammatory acne.
至于病理生理学上的发炎性损害,正常皮肤共生的细菌—丙酸杆菌粉刺起着特殊作用,尽管并不需要分生孢子,但是通过观察发现丙酸杆菌粉刺和感染性损害的发病机制有关系
The density of P. acnes increases markedly during puberty coinciding with the onset of the disease (Leyden et al, 1975). P. acnes is rarely found in animal skin and acne is not seen in animals (Webster et al, 1981; Kearney et al, 1982). Treatments that reduce P. acnes numbers lead to clinical improvement of acne (Thiboutot, 1997) and, finally, the emergence of antibiotic-resistant P. acnes strains a