瑞氏综合征.ppt

Reye syndrome
An acute encephalopathy characterized by fever, vomiting, fatty infiltration of the liver, disorientation, a, occurring mainly in children and usually following a viral infection, such as chicken pox or influenza.
Reye syndrome
a condition in which there is brain damage (encephalopathy) and liver damage of an unknown cause.
It is associated with the use of aspirin to treat chicken pox or influenza in children.Can potentially affects ans of the body , can result in cerebral edema and the accumulation of fat in the liver and ans.
History
In 1963, North Carolina doctor e Johnson reported an epidemic of 16 fatal cases of an encephalitis-like illness during an influenza B outbreak.
Reye syndrome , named after Australian pathologist R. Douglas Reye, who first reported it as a distinct syndrome in 1963.
The syndrome had been reported as early as 1929 but now was identified and characterized as a distinct entity.
Douglas Reye, fatty degeneration of the viscera of unknown cause
Each year between March 1951 and March 1962, the Royal Alexandra Hospital for Children in New South Wales, Australia, admitted one or two children in such a critical state that most of them could not be saved, despite the most advanced medical care.
When admitted, all but two of the 21 children were in a or stupor, although their illness had started out a few days or weeks earlier with mon childhood upper respiratory symptoms
Some children had even appeared to be recovering before the more serious phase of the illness began, with fever, relentless vomiting, convulsions, wild delirium, screaming, intense irritability, and violent movements.
Seventeen of the children died within an average of 27 hours after admission.
At autopsy, all were found to have brain swelling, a slightly enlarged, firm and uniformly bright yellow liver, and a change in the appearance of the kidneys
e Johnson, Reye-Johnson syndrome
In 1963,an epidemic of 16 fatal cases of an encephalitis-like diseas