超声对穿心莲内酯溶析结晶的影响.pdf.pdf

第 22 卷第 4 期高校化学工程学报
2008 年 8 月 Journal of Chemical Engineering of Chinese Universities Aug. 2008
文章编号:1003-9015(2008)04-0585-06
超声对穿心莲内酯溶析结晶的影响

杭方学 1,2, 丘泰球 1
(1. 华南理工大学轻工与食品学院, 广东广州 510640;
2. 广西大学轻工与食品工程学院, 广西南宁 530004)

摘要:研究了超声波对穿心莲内酯溶析结晶过程的影响,考察不同超声功率对均相成核诱导期、介稳区、晶体粒度
和晶形的影响。实验结果表明,超声波显著降低了结晶诱导期,诱导期随着超声功率的增加而缩短。分析了超声对均
相成核影响的机理,在相同过饱和度条件下,诱导期缩短的主要原因是超声波提高了成核过程中的扩散系数,而表面
张力受到声场的影响较小,基本保持不变。超声波引入溶析结晶体系后,晶体的粒度减小,在高功率超声作用下,溶
液中产生了更多晶核降低了晶体生长的速度。经超声波作用的晶体外形发生变化,并且减少了晶体间的聚集。同时超
声波的作用使介稳区宽度明显变窄,表明在超声场中过饱和溶液变得更不稳定。
关键词:溶析结晶;超声波;声结晶;穿心莲内酯
中图分类号:;; 文献标识码:A

Effect of Ultrasound on Andrographolide Solventing-Out Crystallization Process

HANG Fang-xue1,2, QIU Tai-qiu1
(1. School of Light Industry and Food, South China University of Technology, Guangzhou 510640, China;
2. School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China)

Abstract: The influences of ultrasound on the solventing-out crystallization of andrographolide were
investigated. The effect of ultrasound on homogeneous nucleation was studied via measuring the induction time,
metastable zone width, the mean crystal size, and the shape of the crystals obtained. Experiments were carried
out under ultrasound with various energy inputs; results indicate that, with ultrasound, the induction time of