ABSTRACT Nasopharyngeal carcinoma (NPC) is the mon head and neck cancer in South China. Radiotherapy is the primary treatment modality for early-stage NPC. The development of radiation therapy techniques, specifically intensity-modulated radiation therapy, has increased the five-year overall survival (OS) rate of early-stage NPC patients to >90%; however, the OS rate of late-stage NPC patients is only approximately 70%. Some NPC patients still fail with local recurrence and/or distant metastasis. Platinum-bination chemotherapy regimens are usually regarded as standard chemotherapy for metastatic NPC. However, the clinical applications of platinum drugs are limited by their adverse effects. Therefore, chemotherapy regimens with improved efficacy and favourable toxicity are needed. The main aim of this study is to investigate the efficacy and safety of bined with docetaxel for the treatment of recurrent or metastatic NPC. Docetaxel (75 mg/m2) was administered via intravenous infusion on day 1 of each 21-day cycle. Lobaplatin was administered intravenously at a dose of 30 mg/m2 on day 2 of each cycle. The regimen was repeated every 3 weeks. Patients who were eligible for the trial were mended to receive four to six courses. During the chemotherapy, responses were assessed according to RECIST every two cycles. Toxicities were evaluated according to NCI-CTC (version ) before each treatment cycle. All analyses were carried out using IBM SPSS Statistics (version ). From April 2011 to July 2013, 39 patients were recruited. In total, 3 patients (%) plete response (CR), 21 patients (%) had partial response (PR), 9 patients (%) had stable disease (SD), 4 patients (%) had progressive disease (PD) and 2 patients were not evaluated (%). The overall response rate (ORR) was %, and the disease control rate (DCR) was %. The mon grade 3/4 toxicities included leucopaenia and neutropaenia (%), anaemia (%) and increased aminotransferase level (2
