固体脂质体纳米粒.ppt

Solid lipid nanoparticles: an oralbioavailability enhancer vehicle
Name : Li Jing
Major : pharmaceutics
Mentors : Doctor Chen
Contents
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Preparation of cryptotanshinon-loaded SLNs
Optimization of oral SLNs
Introduction
Absorption of drug-loaded SLNs
Conclusion
Background
oral route
nanoparticulate systems.
Liposomes
Nanoemulsions
Polymeric nano
-particles.
Nanosuspensions
advantages
disadvantages
poor oral BA
Description of the contents
Description of the contents
SLNs
Poor oral bioavailability (BA)
Poor
solubility
Hepatic
first-pass
metabolism
Nanoparticles (NPs) are considered as alternatives to various conventional drug delivery techniques .
poor oral bioavail
-ability
Poor permeability
SLNs
SLN are particles made from solid lipids (. lipids solid at room temperature
and also at body temperature and stabilised by surfactant(s) which
diameter are between approximately 50 and 1000 nm
improved oral BA
of drugs
Improved stability
of drugs entrapped
in SLNs
reduced toxicity
reduced
multidrug resistance
(MDR)
state of lipid material.
3. chemical and physical structure of solid lipid matrix;
1. solubility of drug in melted lipid;
of drug melt and lipid melt;
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Factors
Factors determining the loading capacity
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The development of SLN
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1990
1991
1995
2012
The first experiments in the production of lipid nanoparticles were performed in academic labs.
They were followed by two independent patent applications and the first publications appeared shortly afterwards
The first basic review about SLN)appeared which gave an overview of research
groups active in this new field
Their results are reviewed which cover many different administration routes
Advantages of SLNs
Table 1. Advantages of SLNs over other nanoparticulate systems
Methods of preparation of SLNs
Methods of preparation of SLN