纤维蛋白原与冠心病论文.doc

纤维蛋白原与冠心病论文.doc纤维蛋白原与冠心病论文
纤维蛋白原(Fibrinogen,Fg)是血浆中含量较高的大分子蛋白质,它主要通过以下途径参与血液调节:(1)受凝血酶等因子的作用形成不可溶解的纤维蛋白多聚体。(2)与血小板膜上受体结合导致血小板聚集。(3)以其本身或其降解产物影响纤溶系统。近来,大量研究证明,血浆Fg水平与冠心病之间存在密切的联系,现综述如下。 1 Fg的结构与功能
Fg的结构正常血浆中Fg的含量为2~4g/L,其组成是不均一的,但绝大部分为分子量34万的分子,, 1993,81:3186.
2 Veklich YI,Gorkun DV,medved LV,et al. Carboxyl-terminal portions of fibrinogen and Biol Chem,1993,268:13577.
3 Stubbs MT,Oschkinat H,.freelbin , 1992,206:187.
4 Martin PD, Robertson ed Assoc,1987,258,1183.
6Ernat contracep tives,fibrinogen and cardiovascular ,1992,93:1.
7 Stone MC,Thorp J fibrinogen a major cardiovascular risk factor. JR Coll Gen Pract,1985,35,565.
8 Balleisen factora and the progress of coronary heart disease. Lancet,1987,1:461.
9 Yarnell JONICA Augaburg and Thrombosis,1992,12:780.
11 Meade Tenqoauaal status and haemostatil ,1983,1:22.
12 Lee AJ. Plasma fibrinogen and coronary risk factors:the Scottish Heart Clin Epidemiol, 1990,43:913.
13 Love GDC. Increased plasma Fibrinogen and