3 4二氢嘧啶酮需氧氧化脱氢反应和42叠氮基苯基3 4二氢嘧啶酮的反应研究.docx

兰州大学大硕上学位论文 3’-().3,
Abstract
IIl the past decade,dihydropyrimidinones(DHPMs)and their derivatives have attracted considerable interest because they exhibit promising activities as calcium channel blockers,antihypertensive dihydroprimidinones’structure was altered and other pounds were synthesized from dihydro· thesis was mainly focused on the study of DHPMs derivatizing consists of four parts:
In chapter 1,basic knowledge of dihydroprimidinones and dihydroprimidines Was reviewed,in terms of the activities,precursors preparation and derivatizing reaction of dihydroprimidinones in detail.
In chapter 2,Relate reaction and application anic azides were introduced.
In chapter 3,4-Substituted dihydropyriminones and dihydropyfimindines were aerobic oxidized to the corresponding pyrimidinones and pyrimidines,respectively,in lligh yields by molecular oxygen in the presence of catalytic amount of N-hydroxyphthalimide(NHPI)and Co(OAc)2 under a mild and environmental benign
condition
In chapter 4,Photochemical or thermal reactions of 4一(2一azdiophenyl)-
3,4一dihyro-pyrimidinones were introduced.
Keyword:Biginelli reaction,Oxidative Dehydrogenation,NHPFCo+,Organic Azides, Azides Photolysis and Pyrolysis
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兰州大学大硕士学位论文 3'4一一二氢嘧啶酮氧化脱氢反应和4.(2一叠氮摹苯基)-3冉二氢嘧啶酮的反应研究
第一章二氢嘧啶酮的合成和反应简介

二氢嘧啶酮是一种非常重要的药物中间体,它们由于广泛的治疗和药理特性而受到高度的重视,如在抗病毒,抗肿瘤,抗菌,抗炎等方面的效果【l】。此外, 这些化合物已经成为钙通道抑制剂,抗高血压药,a-Ⅵ几个药物结构构成所必须的骨干【21。而且,一些从海洋来源分离得到的生物碱其核心结构也包含二氢嘧啶酮的结构,并表现出一些有趣的生物