肺腺癌中egfr突变丰度与egfr-tki治疗疗效相关性研究.docx

实验结果....................................................................................................18
1. 细胞形态观察............................................................................... 18
2. 提取 DNA 检测 18
3. PC-9、SPC-A1 细胞 EGFR、KRAS 基因突变状态 18
4. 裸鼠成瘤........................................................................................20
裸鼠肿瘤 EGFR 检测 20
组内比较:............................................................................21
EGFR 突变丰度与 EGFR-TKI 的相关性 27
讨论............................................................................................................28 基因突变的检测方法......................................................... 28
................................................................. 29
-TKI 药效与 EGFR 突变丰度相关 29
结论............................................................................................................30
展望............................................................................................................30
参考文献....................................................................................................31
综述............................................................................................................33
参考文献....................................................................................................40
致谢............................................................................................................44
主要中英文缩略词表
英文缩写
英文全称
中文全称
NSCLC
Non-small cell lung cancer
非小细胞肺癌
ATP
Adenosine Triphosphate
三磷酸腺苷二钠
EGFR
Epidermal growth factor receptor
表皮生长因子受体
EGFR mutation
Epidermal growth factor receptor mutation
表皮生长因子受体突变
EGFR-TKI
Epidermal growth factor receptor
表皮生长因子受体
tyrosine kinase inhibitor
酪氨酸激酶抑制剂
DNA
Deoxyribonucleic Acid
脱氧核糖核酸
OD
Optical density
光密度值
T790M
Codon 790 Mutation 790
密码子突变
EGF
Epidermal growth factor
表皮生长因子
TGFa
Transforming growth factor-a
转化生长因子-α
TKIs
Tyrosine kina