Recent Progress on Catalytic Asymmetric Synthesis Albert S. C. Chan The Hong Kong Polytechnic University Louis Pasteur Chemist 1822 - 1895 “Chance favors only the prepared mind.” 从酒石中结晶出来的酒石酸有两种形态,借助于放大镜和镊子可以分开。 威廉·诺尔斯 William S, Knowles, Nobel Laureate 2001 Our book published in 2000! Starting material Hydrogen Hydrogen A: (S)-product, hydrolysis makes L-DOPA. B: (R)-product ee% = (A-B)/(A+B) × 100% Without chiral catalyst: ee = 0; With good chiral catalyst: ee > 99% Monsanto L-Dopa Process Without chiral catalyst: (S)-alanine = (R)-alanine; ee = 0 With chiral catalyst: (S)-alanine >> (R)-alanine; ee > 99% ee% = (A-B)/(A+B) × 100% Production of L-alanine A B 野依良治 Ryoji Noyori, Nobel Laureate 2001
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