论文：鸟嘌呤盐酸盐的检验方法.doc

MOA of Guanine HCL
1、
外观appearance
目视检查。Visual testing
2、
溶液颜色(《中国药典》附录 IX A)
solution color(Chinese pharmacopoeia, appendix IX A)
,加入2mol/L的氢氧化钠溶液溶解至刻度,再与等厚度的Y5对照液进行目视比色,色泽不得比对照液深。
Weigh sample into parison tubes, add 2mol/L NaOH solution, compared to Y5 contrast solution, the color should not be darker than contrast solution.
3、
氮含量测定(《中国药典》二部附录Ⅻ D)
nitrogen testing(Chinese pharmacopoeia, appendix Ⅻ D)
(±)试样,按《中国药典》二部附录Ⅻ D中的第一法进行测定并计算出氮的量N(mg),并按下式计算出试样中氮的百分含量:
Weigh (±)sample, use the first method in Chinese pharmacopoeia, appendix Ⅻ D to calculate nitrogen volume(mg), and get percentage content of nitrogen in the sample according to below method
试样的氮含量nitrogen content in the sample(%)
式中:N——试样中测量出来的氮的量,mg;quantity of nitrogen in the sample
m——试样的质量,g。weight of the sample
4、
干燥失重:《中国药典》二部附录VIII L
losing on drying: Chinese pharmacopoeia, appendix VIII L
~,置于已恒重的扁平称量瓶(带盖)中,精密称定,在105℃下烘3小时。
Weigh ~ sample, into flat weighing bottle, weigh it, then heat under 105℃ for 3 hours.
以质量百分数表示的干燥失重(X)按下式计算
Calculate losing on drying according to below method,
式中:W0——恒重的空瓶的质量,g;empty bottle weight
W1——(空瓶+供试品)的重量,g;empty bottle + sample weight
W2——(空瓶+供试品)炽灼后的重量,g。empty bottle + sample after being heated.
5、
硫酸盐灰分:《中国药典》二部附录VIII N
sulfate ash (Chinese pharmacopoeia, appendix VIII N)
取1.