抑那通治疗前列腺癌的新进展.ppt

抑那通治疗前列腺癌的新进展
AUA(2010)内分泌治疗新进展
bined with androgen deprivation vs. androgen deprivation alone in clinically locally advanced prostate caner in a multicenter randomised phase III study
Nicolas Mottet, France.
AUA(2010)内分泌治疗新进展
INTRODUCTION AND OBJECTIVES
In locally advanced disease, bination of radiotherapy (RT) and androgen deprivation (ADT) is superior to RT alone.
But ADT with an analogue has never pared bined modality.
We report a phase III randomised trial in locally advanced PCa, comparing bined modality and ADT only.
AUA(2010)内分泌治疗新进展
METHODS
In this French multicenter, open, randomised trial, patients less than 80 years, with histologically confirmed PCa, T3-4, or pT3 (biopsy) N0M0 were included.
They were centrally randomised in 2 parallel groups to either ADT alone (leuprorelin mg SR,1 sc injection every 3 months for 3 years or the same bined with RT starting within 3 months over 7 weeks.
AUA(2010)内分泌治疗新进展
RESULTS
HT
HT+RT
P
N
131
133
Mean Age



Mean PSA baseline



Median PFS (days)
1264
2544

PFS (5 year) (%)



Biological progression (%)


<
Clinical progression (%)


<
AUA(2010)内分泌治疗新进展
Prevalence of metabolic syndrome in prostate cancer patients under androgen deprivation therapy: interim results of a case-control study.
Jorge Ropero, Barcelone, Spain.
AUA(2010)内分泌治疗新进展
METHODS
MS was analyzed according the ATPIII panel criteria:
Fasting plasma glucose level >110 mg/dL
serum triglyceride level >150 mg/dL
serum high-density lipoprotein level<40 mg/dL
waist circumference >102 cm
Blood pressure of >130/85 mmHg.
AUA(2010)内分泌治疗新进展
RESULTS
MS was diagnosed in 27 of the 53 patients subjected to ADT (%) while it was detected in 35 of the 105 age-matched controls (%), p = .
However the prevalence of MS was % (19/53) in men without PC and % (16/52) in men with PC, p=.