抑那通治疗前列腺癌的进展-expert.ppt

抑那通治疗前列腺癌的新进展
北京大学第三医院
黄毅
AUA(2010)内分泌治疗新进展
bined with androgen deprivation vs. androgen deprivation alone in clinically locally advanced prostate caner in a multicenter randomised phase III study
Nicolas Mottet, France.
AUA(2010)内分泌治疗新进展
INTRODUCTION AND OBJECTIVES
In locally advanced disease, bination of radiotherapy (RT) and androgen deprivation (ADT) is superior to RT alone.
But ADT with an analogue has never pared bined modality.
We report a phase III randomised trial in locally advanced PCa, comparing bined modality and ADT only.
AUA(2010)内分泌治疗新进展
METHODS
In this French multicenter, open, randomised trial, patients less than 80 years, with histologically confirmed PCa, T3-4, or pT3 (biopsy) N0M0 were included.
They were centrally randomised in 2 parallel groups to either ADT alone (leuprorelin mg SR,1 sc injection every 3 months for 3 years or the same bined with RT starting within 3 months over 7 weeks.
AUA(2010)内分泌治疗新进展
RESULTS
AUA(2010)内分泌治疗新进展
Prevalence of metabolic syndrome in prostate cancer patients under androgen deprivation therapy: interim results of a case-control study.
Jorge Ropero, Barcelone, Spain.
AUA(2010)内分泌治疗新进展
INTRODUCTION AND OBJECTIVES
Cardiovascular mortality is the most important cause of death in patients with prostate cancer (PC).
The development of metabolic syndrome (MS) in patients undergoing androgen deprivation therapy (ADT) has been related with this increase in mortality rate.
The aim of this study has been to confirm the hypothesis that ADT increases the prevalence of MS.
AUA(2010)内分泌治疗新进展
METHODS
A group of 157 patients were enrolled in this interim analysis of a prospective case control study.
53 PC patients under ADT during a mean time of 52 months (6 to 252) and 104 age matched controls evaluated at the time of prostate biopsy (52 with cancer and 52 without) were included.
AUA(2010)内分泌治疗新进展
METHODS
MS was analyzed according the ATPIII panel criteria:
Fasting plasma glucose level >11