抑那通治疗前列腺癌的新进展.pptx

AUA(2010)内分泌治疗新进展
Radiotherapy combined with androgen deprivation vs. androgen deprivation alone in clinically locally advanced prostate caner in a multicenter randomised phase III study
Nicolas Mottet, France.
AUA(2010)内分泌治疗新进展
INTRODUCTION AND OBJECTIVES
In locally advanced disease, the combination of radiotherapy (RT) and androgen deprivation (ADT) is superior to RT alone.
But ADT with an analogue has never been compared to combined modality.
We report a phase III randomised trial in locally advanced PCa, comparing a combined modality and ADT only.
AUA(2010)内分泌治疗新进展
METHODS
In this French multicenter, open, randomised trial, patients less than 80 years, with histologically confirmed PCa, T3-4, or pT3 (biopsy) N0M0 were included.
They were centrally randomised in 2 parallel groups to either ADT alone (leuprorelin mg SR,1 sc injection every 3 months for 3 years or the same ADT combined with RT starting within 3 months over 7 weeks.
AUA(2010)内分泌治疗新进展
RESULTS
HT
HT+RT
P
N
131
133
Mean Age



Mean PSA baseline



Median PFS (days)
1264
2544

PFS (5 year) (%)



Biological progression (%)


<
Clinical progression (%)


<
AUA(2010)内分泌治疗新进展
Prevalence of metabolic syndrome in prostate cancer patients under androgen deprivation therapy: interim results of a case-control study.
Jorge Ropero, Barcelone, Spain.
AUA(2010)内分泌治疗新进展
INTRODUCTION AND OBJECTIVES
Cardiovascular mortality is the most important cause of death in patients with prostate cancer (PC).
The development of metabolic syndrome (MS) in patients undergoing androgen deprivation therapy (ADT) has been related with this increase in mortality rate.
The aim of this study has been to confirm the hypothesis that ADT increases the prevalence of MS.
AUA(2010)内分泌治疗新进展
METHODS
A group of 157 patients were enrolled in this interim analysis of a prospective case control stud