伊维菌素ivermectin（伊维菌素ivermectin）.doc

伊维菌素ivermectin（伊维菌素ivermectin）.doc伊维菌素ivermectin(伊维菌素ivermectin)
Ivermectin
medical aircraft
Ivermectin ivermectin is a new broad-spectrum, high efficiency and low toxicity of antibiotics and antiparasitic drugs, especially in vivo of parasite nematode and arthropod animal has good killing effect. But it is invalid for tapeworm, fluke and protozoa. Macrolide antiparasitic drugs on nematode and arthropod animal killing effect is to increase the inhibitory neurotransmitter gamma aminobutyric acid GABA worm) release, and open the Cl ion channel glutamate control, enhance the permeability of nerve membrane to Cl, thereby blocking the transmission of nerve signals, eventually paralysis, make muscle cells lose their contractile ability, and lead to the parasite.
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brief introduction
Character
Pharmacology and pharmacodynamics
ics
purpose
Drug interaction
Function indications
clinical research
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Ivermectin Ivermectin
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Ivermectin
By Streptomyces avermitilis (Streptomyces avermitilis) semi synthetic macrolide antibiotics produced by fermentation of ponent. The main content of ivermectin B1 (Bla+B1b) is not less than 93%, which shall not be less than 85% Bla. B1 22,23- dihydro ivermectin avermectin B1
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This product is white crystalline powder, tasteless. This product is soluble in methanol, ethanol, acetone and ethyl acetate, almost insoluble in water.
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Pharmacodynamics
Because the fluke and tapeworm do not use GABA as a transmitter, they lack Cl channels controlled by glutamate. Therefore, this kind of medicine is invalid. Although the peripheral neurotransmitter of mammalian is acetylcholine, although GABA is d