492 ISSN 1007-3949 Chin J Arterioscler, Vol 16, No 6, 2008 #临床研究# [ 文章编号] 1007- 3949( 2008) 16- 06- 0492- 03 替米沙坦对高血压合并糖尿病患者血清脂联素的影响 陈远刚, 陈明 ( 重庆医科大学附属第一医院心内科, 重庆市 400016) [ 关键词] 内科学; 高血压; 糖尿病; 替米沙坦; 脂联素 [ 摘要] 目的观察替米沙坦治疗前、后高血压合并糖尿病患者血清脂联素水平的变化。方法将 50 名门诊 高血压合并糖尿病病人分为替米沙坦和氨氯地平两组。观察治疗前及治疗 10 周后患者血压、脂联素及血糖、胰岛 素变化。结果与治疗前相比, 替米沙坦组与氨氯地平组收缩压和舒张压均显著降低( P < 0. 01) , 替米沙坦组血清 脂联素水平较治疗前显著升高( P< 0. 01) , 血糖、胰岛素和胰岛素抵抗较治疗前显著降低( P < 0. 01) ; 氨氯地平组治 疗前后血清脂联素、血糖、胰岛素和胰岛素抵抗无明显改变( P > 0. 05) 。结论与氨氯地平相比, 替米沙坦在降压 的同时, 显著增高了血清脂联素水平并显著改善胰岛素抵抗, 显示其具有降压外良好的代谢效应。 [ 中图分类号] R5 [ 文献标识码] A Effect of Telmisartan on the Level of Serum Adiponectin in Hypertensive Patients with Type 2 Diabetes Mellitus CHEN Yuan-Gang, and CHEN Ming ( Department of Cardiology , the First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016, China ) [ KEY WORDS] Hypertension; Diabetes Mellitus; Telmisartan; Adiponectin [ ABSTRACT] Aim To investigate the effect of telmisartan on adiponectin in hypertensive patients with type 2 diabetes mellitus. Methods In this prospective study, 50 hypertensive patients with type 2 diabetes mellitus were treated either with telmisartan or with amlodipine for 10 weeks. The serum concentration of fasting adiponectin, glucose, insulin and blood pressure ( BP) were measured at baseline and after treatment respectively. Results The sy
