赤芍与白芍的药理作用比较研究.doc

赤芍与白芍的药理作用比较研究
王瑞1,2,鲁岚1,李颖伟1,胡月娟1,王峥涛1,2*
(,上海 201203;,上海 201203)
[摘要] 目的:对赤芍和白芍的80 %乙醇提取物及其脂溶性成分和水溶性成分进行药理活性比较研究,为阐明其药效物质奠定基础。方法:以二甲苯致小鼠耳肿胀法和醋酸致小鼠腹腔毛细血管渗出法比较赤芍和白芍的抗炎作用;以凝血流变学指标和ADP诱导血小板聚集比较赤芍和白芍的活血化瘀作用。结果:赤芍与白芍的提取物及其脂溶性和水溶性成分均有不同程度的抗炎以及抑制血小板聚集作用,均有明显延长部分凝血活酶时间的作用,而均无明显延长凝血酶原时间的作用。结论:白芍总提物对抑制炎性水肿和炎性渗出均有很好的效果,而在抑制血小板聚集方面,赤芍总提物的作用明显优于白芍总提物。
[关键词] 赤芍;白芍;药理作用;抗炎;凝血
[中图分类号] [文献标识码] [文章编号]
Experimental Study of Pharmacological Action of Radix Paeoniae Rubra and Radix Paeoniae Alba
WANG Rui1,2, LU Lan1, LI Ying-wei1, HU Yue-juan1, WANG Zheng-tao1,2*
(1. Shanghai University of Traditional Chinese Medicines, Shanghai 201203, China; 2. Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai 201203, China)
[Abstract] Objective: To discuss the differences of Radix Paeoniae Rubra and Radix Paeoniae Alba, parative pharmacodynamical study was carried separately. Method: To observe the influence of elution parts of Radix Paeoniae Rubra and Radix Paeoniae Alba on inflammatory and blood coagulation. Results: The experimental extracts have shown effects of anti-inflammatory and promoting blood coagulation. Conclusion: The extract of Radix Paeoniae Alba has shown obvious effects of anti-inflammatory. The extract of Radix Paeoniae Rubra by has shown better effect of promoting blood coagulation.
[Key words] Radix Paeo