读书报告.pdf

T h e ne w engl a nd jour na l o f medicine
original article
Hydroxyethyl Starch 130/ versus Ringer’s
Acetate in Severe Sepsis
Anders Perner, ., ., Nicolai Haase, .,
Anne B. Guttormsen, ., ., Jyrki Tenhunen, ., .,
Gudmundur Klemenzson, ., Anders Åneman, ., .,
Kristian R. Madsen, ., Morten H. Møller, ., ., Jeanie M. Elkjær, .,
Lone M. Poulsen, ., Asger Bendtsen, ., ., Robert Winding, .,
Morten Steensen, ., Pawel Berezowicz, ., ., Peter Søe-Jensen, .,
Morten Bestle, ., ., Kristian Strand, ., ., Jørgen Wiis, .,
Jonathan O. White, ., Klaus J. Thornberg, ., Lars Quist, .,
Jonas Nielsen, ., ., Lasse H. Andersen, ., Lars B. Holst, .,
Katrin Thormar, ., Anne-Lene Kjældgaard, ., Maria L. Fabritius, .,
Frederik Mondrup, ., Frank C. Pott, ., ., Thea P. Møller, .,
Per Winkel, ., ., and Jørn Wetterslev, ., .,
for the 6S Trial Group and the Scandinavian Critical Care Trials Group*
ABSTR ACT
Background
Hydroxyethyl starch (HES) 130/ is widely used for fluid resuscitation in intensive The authors’ affiliations are listed in the
care units (ICUs), but its safety and efficacy have not been established in patients with Appendix. Address reprint requests to
Dr. Perner at the Department of Intensive
severe sepsis. Care 4131, Rigshospitalet, Blegdamsvej 9,
Methods DK-2100 Copenhagen, Denmark, or at
anders.******@.
In this multicenter, parallel-group, blinded trial, we randomly assigned patients
with severe sepsis to fluid resuscitation in the ICU with either 6% HES 130/ or *Members of the Scandinavian Starch
Ringer’s acetate at a dose of up to 33 ml per kilogram of ideal body weight per day. for Severe Sepsis/Septic Shock (6S) tri-
al group are listed in the Supplementa-
The primary e measure was either death or end-stage kidney failure (depen- r