肺炎衣原体感染与缺血性脑卒中及其亚型的相关性分析 童伟周淑芬尹家保 (湖北医药学院附属襄阳医院湖北襄阳 441000) 摘要目的:检测各种缺血性脑卒中(AIS)患者血浆中肺炎衣原体(Cpn)各种抗体水平,探讨AIS和Cpn感染的相关性。方法:收集62例AIS患者和48例健康对照者血浆,用ELISA方法检测CpnIgG、IgA、IgM水平。结果:AIS组CpnIgA阳性率明显高于健康对照组(p<),各种亚型AIS患者间CpnIgA和CpnIgG抗体阳性率无显著性差异。结论:Cpn新近感染与AIS相关,可能参与AIS的疾病发生发展过程。 Abstract Object:To detect the level of Chlamydia pneumoniae(Cpn)antibody in the plasma of patients with acute ischemic stroke(AIS) and investigate the correlation of AIS and Cpn :CpnIgG、CpnIgA and CpnIgM were detected in 62 plasma samples of AIS and 48 that of healthy controls with :The positivity of CpnIgA in patients with AIS was higher than that in healthy controls(p<).There was no difference in IgA or IgG positivity between different stroke of patients positive for IgM were too small to :Cpn recent infection was related to AIS and might involve in the trigger and development of AIS. 关键词:缺血性脑卒中肺炎衣原体 ELISA 肺炎衣原体(Chlamydia pneumoniae,Cpn)是一种革兰氏阴性、严格细胞内寄生的病原微生物,通常引起上呼吸道感染,且多为无症状感染。每5-7年就会有肺炎衣原体广泛流行的报道,在自然人群中的血清阳性率为50-70%【1】。自从1985年肺炎衣原体被证实可引起临床感染以来,肺炎衣原体感染与动脉粥样硬化和脑卒中的关系一直成为世界各地研究的热点【2】。尽管预期的队列研究还没有确认这一相关性,但很多证据支持动脉粥样硬化和心脑血管疾病与肺炎衣原体感染相关【3-4】。肺炎衣原体感染与缺血性脑卒中(acute ischemic stroke ,AIS)的相关性研究已被大量血清学实验和抗生素干预实验证明【5-7】,但由于缺血性脑卒中及其亚型的发病机制的复杂性,肺炎衣原体感染对急性中风来说是起因、促进还是触发还是有争议的【8】。相对西方国家而言,我国感染性疾病仍然十分普遍,我们着手调查襄阳地区AIS病人血清中Cpn抗体水平与AIS及其亚型的关系,进而探讨Cpn
