《宫内发育迟缓的孕前因素研究.》.pdf.pdf

中南大学学报(医学版)
2013, 38(11) ; http://xbyx.
J Cent South Univ (Med Sci) 1099
DOI:.1672-
http://xbyx./xbwk/fileup/PDF/
宫内发育迟缓的孕前因素研究
胡丽1,谭红专1,周书进2,何玥1,沈琳1,柳祎1,文师吾1
(1. 中南大学公共卫生学院流行病与卫生统计学系,长沙 410078;2. 浏阳市妇幼保健院,长沙 410300)
[摘要]目的:探讨胎儿宫内发育迟缓的孕前影响因素。方法:采用巢式病例对照研究方法,将在湖南省浏阳市14
个乡镇妇幼保健所就诊的1368名育龄妇女纳入孕前队列,追踪其妊娠结局。将在随访期内发生的宫内发育迟缓儿作
为病例组,从该队列已分娩的正常新生儿中按1:3匹配抽取对照。采用单因素卡方检验和多因素条件logistic回归分析
胎儿宫内发育迟缓的孕前影响因素。结果:孕前BMI(OR=)、腰围(OR=)、流产史(OR=)、总胆固醇水
平(OR=)、叶酸水平(OR=)、皮质醇水平(OR=)与宫内发育迟缓的发生有关。结论:宫内发育迟缓与孕
前BMI、腰围、流产史、总胆固醇水平、叶酸水平、皮质醇水平有关。加强孕前血液生化指标的检测以指导孕前保
健,并根据孕前BMI和腰围适当增加孕妇营养,可能是预防宫内发育迟缓的有效措施。
[关键词] 宫内发育迟缓;孕前因素;巢式病例对照研究
Pre-conception factors for intrauterine growth retardation
HU Li1, TAN Hongzhuan1, ZHOU Shujin2, HE Yue1, SHEN Lin1, LIU Yi1, WEN Shiwu1
(1. Department of Epidemiology and Health Statistics, Central South University, Changsha 410078;
2. Child and Maternal Health Care Hospital of Liuyang, Changsha 410300, China)
ABSTRACT Objective: To analyze the pre-conception factors for intrauterine growth retardation.
Methods: A nested case-control study was conducted in a cohort of 1368 women from 14 Child and
Maternity Health Care Departments by cluster sampling method in Liuyang City, Hunan Province.
Following-up until delivery, we collected their medical records and maternal healt