2 327株结核分支杆菌耐多药情况分析
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作者:张廷梅,王燕,骆科文,熊敏,龙应林,蔡翠
【摘要】目的: 了解当前结核病对一线及二线抗结核药物的耐药性及耐多药情况,为结核病防治提供依据。方法: 采用WHO推荐的药敏测试法对2 327株临床分离的结核分支杆菌进行药物敏感性试验。结果: %,%;%,%;并在102例耐多药结核病患者中发现9例严重耐多药结核病。结论: 本地结核菌耐药率高于全,耐药病例中初始耐药率较高,并已发现严重耐药结核病患者,建议积极开展耐药菌监测指导临床选择治疗方案。
【关键词】结核; 分支杆菌,结核; 药物耐受,细菌
[Abstract] Objective: To investigate the resistance status of Bacillus tuberculosis to antituberculosis drugs of fist and second ranks in use, and so as to provide basic data for tuberculosis (TB)prevention . Methods: Drug sensitivity of 2327 strains of B. tuberculosis isolated from clinic patients during 20032009 was tested with WHO mended method. Results: The general dru
g resistance rate was %, and multidrug resistance rate %. The drug resistance data of the last 2 years showed that the primary drugresistance occupied %, and the acquired drugresistance %. Nine cases of extraordinary drugresistance (XDRTB) were found among the 102 cases of multidrug resistance (MDRTB). Conclusions: The local drugresistance rate of B. tuberculosis in Guiyang City is higher than the national average. The primary drugresistance is relatively high, and there occur XDRTB patients. It is suggested that drugresistance mornitoring should be carried out, and so as to provide data for designing treatment p
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