薄层液基细胞学在宫颈病变筛查中的应用.doc

薄层液基细胞学在宫颈病变筛查中的应用
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作者:胡静姿陆勤燕徐海苗
【摘要】目的探讨薄层液基细胞学检测技术在宫颈病变筛查中的应用价值。方法回顾性分析2007年3~7月间南京军区杭州疗养院妇科体检中3 580例ThinPrep液基细胞学检查结果,并对上皮细胞异常者进行随访以获得组织学病理结果,然后行对照相关性分析。结果上皮细胞异常者190例,%,包括ASC-US 102例(%),ASC-H 5例(%),LSIL 69例(%),HSIL 14例(%)。通过随访获得167例阴道镜病理组织学结果,%,细胞学为ASC-%经病理证实为CIN。相关性分析提示TCT结果异常者检出CIN的风险(RR)远高于普通人群。组间比较得出, ASC-US组与LSIL组检出CINⅡ、CINⅢ/CIS的RR值差异没有统计学意义(P=,),ASC-US组与HSIL组检出CINⅠ的RR值差异也没有统计学意义(P=),其他组间比较的差异均存在统计学意义(P<,数据未显示)。结论 TCT技术应用于宫颈病变筛查,能有效提高宫颈癌前病变及宫颈癌的检出率,且结果与病理组织学对照符合率较高,是宫颈病变筛查的有效方法。对细胞学诊断为ASC-US者应予重视,及时进行高危型HPV检测,必要时进行阴道镜检查。
【关键词】膜式薄层液基细胞学检测术(TCT);宫颈上皮内瘤变(CIN);筛查
【Abstract】 Objective To study the value of ThinPrep cytology test (TCT) in screening cervical intraepithelial Examinination results of 3580 cases who were received TCT in health examination in Hangzhou sanatorium ,Nanjing mand from March to July,2007 were retrospectively cases with abnormal result were followed up and confirmed by histopathologic analysis was The results of TCT demonstrated that there were 190 cases with abnormal epithelial cells among 3 580 cases(%),including 102 cases of ASC-US (%),5 cases of ASC-H (%),69 cases of LSIL(%)and 14 cases of HSIL(%).167 cases were received further pathological exami