藏药降糖舒胶囊对四氧嘧啶糖尿病小鼠的防治作用研究
【摘要】目的研究藏药降糖舒胶囊对四氧嘧啶所致糖尿病小鼠的血糖的调节作用。方法从小鼠尾静脉注射100m g/kg的四氧嘧啶造成糖尿病小鼠模型,以藏药降糖舒胶囊1,2,3 g/kg连续灌胃糖尿病小鼠7d后,测定其空腹血糖并进行糖耐量实验。结果藏药降糖舒胶囊2,3g/kg具有降低糖尿病模型小鼠空腹血糖及餐后血糖的作用,且降血糖效果随其剂量增加而增强。结论藏药降糖舒胶囊对四氧嘧啶糖尿病小鼠的高血糖有防治作用。
【关键词】藏药降糖舒胶囊四氧嘧啶降血糖
Abstract:ObjectiveTo explore the effect of Tibetan medicine Jiangtangshu capsule on blood glucose in diabetes mice. MethodsAlloxan-induced diabetic mice were fed Tibetan medicine Jiangtangshu capsules at dosage of 1,2,3g/kg respectively for blood glucose levels and glucose tolerance test of diabetic mice were assayed. ResultsTibetan medicine Jiangtangshu capsule at dose of 2,3g/kg could significantly lower the fasting blood glucose and boold glucose of 60 ,120 min after taking glucose in glucose tolerance test in diabetic mice ,furthermore the hypoglycemic effect increased with the increase of dose of Tibetan medicine Jiangtangshu medicine Jiangtangshu capsules has anti-diabetic effect.
Key words:Tibetan medicine Jiangtangshu capsules; Alloxan ; Reducing blood glucose
糖尿病是遗传因素和环境因素长期作用所致的一种慢性全身性代谢疾病,常发生心血管、眼、神经等方面的并发症[1]。藏药降糖舒胶囊来自于著名藏医措如活佛治疗糖尿病的经典验方。本方根据藏医理论,遵循标本兼治相互协助、相互制约、取长补短的原则组方,主要由寒水石、诃子、红景天、五灵脂、红花、翼首草、大黄、干姜、藏木香、碱花等33味藏药组成,具有益气养阴、活血化淤、健脾和胃、分清泌浊的功效。本文拟通过建立小鼠四氧嘧啶糖尿病动物模型,观察藏药降糖舒胶囊对小鼠血糖的影响,探讨藏药降糖舒胶囊对小鼠高血糖的防治作用,为其临床应用提供充分的药理学依据。
1 材料与仪器
药物藏药降糖舒胶囊(早、中、晚):深棕黄色或黑色干燥粉末,气微香,由西藏措如活佛提供
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