急性冠状动脉综合征病人血清sgp130与cTnI动态变化及意义.doc

急性冠状动脉综合征病人血清sgp130与cTnI动态变化及意义
作者:陈文一滕静刘成玉王元松逄帅
【摘要】目的探讨急性冠状动脉综合征(ACS)病人血清可溶性糖蛋白130(sgp130)和肌钙蛋白I(cTnI)的变化及其临床意义。方法采用ELISA法检测34例急性心肌梗死(AMI)和33例不稳定型心绞痛(UA)病人发作时和缓解后血清sgp130和cTnI浓度的变化,并与36例健康查体者(对照组)进行比较。结果UA病人发作时和缓解后、AMI病人胸痛发生后不同时间血清sgp130浓度明显降低,cTnI浓度明显升高,与对照组比较差异有显著性(F=~,q=~,P<、);UA病人发作时血清sgp130水平明显降低,cTnI浓度明显升高,与缓解后比较差异有显著性(F=、,q=、,P<)。AMI病人胸痛发生后不同时间的血清sgp130、cTnI浓度之间比较,差异均有显著性(F=、,q=~,P<、)。AMI病人胸痛发生后24 h、3 d和7 d血清sgp130浓度变化与UA病人发作时和缓解后比较,差异有显著性(q=~,P<、),胸痛发生后24 h、3 d血清cTnI浓度与UA病人发作时和缓解后比较差异有显著性(F=,q=~,P<、)。结论血清sgp130和cTnI浓度的动态变化对AMI早期诊断具有明显的价值,其变化程度可以作为炎症反应和病情严重程度的判断指标之一。
【关键词】冠状动脉疾病;可溶性糖蛋白130;肌钙蛋白I;酶联免疫吸附测定
[ABSTRACT]ObjectiveTo explore the dynamic changes and their clinical significance of serum cardiac troponin I (cTnI) and soluble glycoprotein-130 (sgp130) in patients with acute coronary syndrome (ACS).MethodsThe serum cTnI and sgp130 of 34 patients with acute myocardial infarction (AMI) and 33 with unstable angina (UA) were determined by enzyme-linked immunosorbent assay (ELISA) at attack and at remission, 36 healthy subjects served as with the controls, serum sgp130 levels were lower and cTnI higher in UA patients at the attack and remission, and in AMI patients at different times after the onset of ch