驻极体氟尿嘧啶凝胶贴剂的制备研究.pdf.pdf

药学实践杂志 2015 年 5 月 25 日第 33 卷第 3 期
, .33 , .3 , 25 ,2015 217
Journal of Pharmaceutical Practice Vol No M ay
· 论著·
驻极体氟尿嘧啶凝胶贴剂的制备研究
1 2 1 ,2 1 ,2
韦平艳,苑旺,杨峰,崔黎丽(1 .福建中医药大学,福建福州 350122 ;2 .第二军医大学药学院,上海 200433)
[摘要] 目的制备并优化驻极体氟尿嘧啶凝胶贴剂及考察贴剂的相关性质。方法通过预实验筛选黏合剂和保湿
剂,采用正交设计优化处方,用补偿法测量驻极体贴剂的电荷储存稳定性,用透皮扩散仪和仪研究药物的体外透皮作
HPLC
用。结果贴剂基质的最佳配比为∶明胶∶∶高岭土∶唱∶保湿剂= 0 .2 ∶ 0 .7 ∶ 0 .5 ∶ 0 .7 ∶ 0 .2 ∶ 12 ;制
PAAS PVA CMC Na
备的贴剂具有良好的电荷储存稳定性;驻极体和 3% 氮酮均能有效地促进药物释放,且两者有协同促渗作用。结论按最佳
条件制备了质量优良的驻极体氟尿嘧啶凝胶贴剂,该贴剂对皮肤无刺激性,且该贴剂的药物释放行为优于一般的凝胶贴剂。
[关键词] 驻极体;氟尿嘧啶;凝胶贴剂;透皮吸收
[中图分类号] 944 [文献标志码] [文章编号] 1006唱0111(2015)03唱0217唱04
R A
[DOI] 10 .3969/ . .1006唱0111 .2015 .03 .007
j issn
The preparation of electret fluorouracil gel patch
1 , 2 , 1 ,2 , 1 ,2 (1 . ,
WEI Pingyan YUAN Wang YANG Feng CUI Lili Fujian University of T raditional Chinese Medicine Fuzhou
350122 , ;2 . , , 200433 , )
China School of Pharmacy Second Military Medical University Shanghai China
[Abstract] Objective 唱
To study and optimize the preparation process and abserve the related properties of electret flu
.Methods .
orouracil gel patch the adhesives and moistening agents were screened by preliminary experiment The optimal
.
matrix proportion in the blank gel patch was obtained with orthogonal design The charge storage stability of the patch was
.
studied pensation method The transdermal behavi