经颅磁刺激系统控制电路设计及其仿真分析.pdf

河北工业大学
硕士学位论文
经颅磁刺激系统控制电路设计及其仿真分析
姓名:王华建
申请学位级别:硕士
专业:生物医学工程
指导教师:徐桂芝
20071101
河北工业大学硕士学位论文
经颅磁刺激系统控制电路设计及其仿真分析

摘要

经颅磁刺激(TMS)是用于刺激人体中枢及周围神经组织的一项无创、无痛的新技术,
其基本原理是利用时变磁场在组织内产生感生电流,直接刺激皮层神经元而改变后者功
能。经颅磁刺激器工作时不需要跟人体有直接的物理接触,整个过程无创、无痛且易于重
复,并且进入人体的磁场无明显的衰减,因此相比于传统的电刺激有很多优点,该技术目
前已经广泛应用于学术研究、诊断、治疗等领域中。
根据河北省自然科学基金资助项目“经颅磁刺激系统设计及其对肢体神经影响的研
究”(编号:E2006000037)的任务要求,本文对经颅磁刺激系统进行仿真分析的基础上,
完成了整个系统的设计。
本文主要是完成经颅磁刺激系统主电路及其控制电路的设计。首先详细分析了经颅磁
刺激器的基本原理,并用OrCAD进行了详尽的仿真分析,给出了较为合理的系统参数,设
计了充放电回路,然后设计了基于单片机的控制系统,实现了对系统充放电控制和应急处
理。最后设计实现了单脉冲经颅磁刺激系统,并对所设计系统提出了改进措施,为经颅磁
刺激技术的发展开辟了思路。

关键字:经颅磁刺激,时变磁场,仿真分析,电路设计

I
河北工业大学硕士学位论文

TRANSCRANIAL IC STIMULATOR
AND ITS CONTROL CIRCUIT DESIGN
AND STIMULATION ANALYSIS



ABSTRACT


Transcranial ic stimulation (TMS) is a relatively new technique, which is
non-invasive and painless, is used to simulate the central and peripheral neural tissues. The
principle is inducing the induced current by external time-varying ic fields to stimulate
the cerebral cortex neuron and change its function. TMS do not need to contact on the human’s
body directly during the whole stimulation process, so it is non-invasive, painless, and it can be
repeated easily. The ic not attenuate evidently. It is more advantage than the tradition
electric stimulate. It has been used widely in academic research, diagnoses, therapy and so on.
According to the Natural Science Foundation of Hebei Province under Grant E2006000037,
fulfilled design the TMS system based on the stimulation analysis of its principle.
This paper focuses on the design of TMS system, which includes the master circuit and its
control circuit design. Firstly analyzes the basic principle and stimulates it detailed by OrCAD
and the reasonable parameters of the TMS was given. Design the charge and discharge circuits.
Then design the control circuits, which control the charge and discharge of the TMS and deal the
exigen