附子灵和尼奥宁的药理研究进展.doc


附子灵和尼奥宁的药理研究进展#
1,2 1,2 1,2 1,2**
(1. 成都中医药大学药学院,四川成都 611137;
2. 中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都 611137)
摘要:通过分析总结国内外有关附子灵和尼奥宁的药理研究方面文献,发现两者的药理研究主要集中在心
血管系统、镇痛、局部麻醉、抗肿瘤、杀虫等方面,且两者均欠缺全面系统的药理学研究。
关键词:中药药理学;附子灵;尼奥宁;药理研究
中图分类号:R285
The pharmacological research progress of Fuziline and
Neoline
Li Yan1,2, Li Yunxia1,2, Gong Xiaohong1,2, Peng Cheng1,2
(1. Chengdu University of Traditional Chinese Medicine College of Pharmacy,Chengdu Sichuan
611137;
2. Research and development of traditional Chinese medicine resources system utilization,
Ministry of State Key Laboratory Breeding Base,Chengdu Sichuan 611137)
Abstract: By analyzing and summarizing pharmacological research literature about Fuziline and
Neoline domestic and foreign literature, the pharmacological research of both drugs are found to
be mainly concentrated on the cardiovascular system, analgesia, anesthesia, antitumor, insecticidal,
and so on. At the same time, Fuziline and Neoline are lacking of prehensive and systematic
pharmacological research.
Key words: Pharmacology of TCM; Fuziline; Neoline; Pharmacological research
0 引言
附子为毛茛科植物乌头(Aconitum carmichaeli Debx.) 的子根的加工品,被 2010 版
《中华人民共和国药典》收载;其味辛、甘,性大热,有毒,归心、肾、脾经;具有回阳救
逆、补火助阳、逐风寒湿邪的功效,常用于亡阳虚脱、肢冷脉微、阳痿、宫冷、心腹冷痛等
[1]
湿、麻醉止痛、免疫抑制等作用

[2,3]

[4]
附子的化学成分主要为生物碱,在国内药用的 51 种乌头属植物中,二萜生物碱被认为是其
[5]
碱、中乌头碱和次乌头碱一般毒性较大,是引起中毒的主要原因,一般须经炮制后才能使用
[6]