蟾酥注射液联合化疗治疗晚期非小细胞肺癌的临床研究..doc

蟾酥注射液联合化疗治疗晚期非小细胞肺癌的临床研究        [08-06-0309:31:00]    编辑:studa20       作者:赵建清,邢立强,李旺,张淑平,李桂林,钱海红【关键词】 非小细胞肺癌;,,化疗;,,蟾酥注射液;,,免疫功能摘要:目的比较蟾酥注射液加化疗与单纯化疗对晚期非小细胞肺癌的疗效、毒性反应及免疫功能的影响。方法将83例晚期非小细胞肺癌患者随机分为两组。治疗组化疗同时加用蟾酥注射液20ml加5%葡萄糖液500ml静脉滴注,1次/d,连用8~10d。对照组单纯化疗。化疗方案为NP方案,即诺维本(NVB)联合顺铂(DDP),28d为1周期,连续两个周期。%,%,差异无显著性(P<)。结论蟾酥注射液配合化疗治疗晚期非小细胞肺癌,可降低化疗对患者免疫功能的影响,改善患者的生活质量。关键词:非小细胞肺癌; 化疗; 蟾酥注射液; 免疫功能 binedwithChemotherapyintheTreatmentofAdvancedNonSmallCellLungCancer Abstract:parethetherapeuticeffect,binedBufalinInjectionwiththoseofchemotherapyaloneinthetreatmentofadvancednon-smallcelllungcancer(NSCLC).,NPplusbufalin20mlweregivenintravenouslybydissolvingin500mlofglucosefluid,perdayfor8~,(25mg/m2,d1,8)andplatinum(DDP)(40~50mgd~3)waschoseninthechemotherapy,28daysisacycle,%%respectively,withoutsignificantdifferencebetweenthetwogroups(P>).Buttherateofclinicaleffect,qualityoflifeKPSgrades,andchangeimmunityin thetrialgroupwerealllowerthanthoseinthecontrol group(P<).binedwithbufalinshowsbenefitinthetreatmentofadvancedNSCLC,bufalincoulddecreasetheinfluenceonimmunity,andimprovethequalityoflifeinpatientswithNSCLC. K