洛铂单药治疗非小细胞肺癌.doc

洛铂单药治疗非小细胞肺癌.doc:..洛钳单药治疗非小细胞肺癌刘卓星\程越,杨海劲,山丹,黄国庆(河源市人民医院肿瘤屮心河源,517000)【摘要】目的探讨洛钳单药方案对晚期非小细胞肺癌的临床疗效。方法选择初治的I11ZIV期非小细胞肺癌(ZQ,予以4周期含洛钳两药方案化疗后病情未进展的患者(完全缓解者剔除)58例分为对照组Z8)和观察组心0),对照组仅予最佳支持关怀治疗(旳观察组予洛钳30n^M第1天,静脉滴注,21天为1个周期同时给予最佳支持关怀治疗。治疗至病情进展。以中位无进展生存吋间(PFS、生活质量(QDD和不良反应作为观察指标。观察组患者至少完成3个周期的维持治疗,最多5个周期,共完成131个周期。结果观察组的PFS为62个月,较对照组的29个月长,差异显著曲・05)。观察组QDL好转率为63眺高于对照组的42盛异显著E05)o不良反应两组比较无统计学差异(0005)。结论洛钳单药用于晚期冋丄的维持治疗能够延长PRS提高QDL不良反应可以耐受。【关键词】洛钳;非小细胞肺癌;维持治疗AStudyofLobapIatinasasingIeagentinthemaintenaneetreatmentofnon—smalIceIIIungcancer1通讯作者,广东省河源市人民医院肿瘤中心,河源517000Broai1:1iuzhuoxi rnLiuzhuo-^cing1,Chengyue,Yanghai^jingTiandanHianggucr-qingDepartmentofOncology;Heyuanpeople7shospital,Heyuan517000,China[Abstract][Objective]Tostudytheefficiencyandadverseeffectsofusinglobaplatintotreatnorr-smal1celllungcancer^fethods]Choiceofinitialtreatmentof11IBIVstagenonsmallcelllungcancerCSSCLjOpatientsfailedtoprogress,mpleteremissionaftere1iminating)58casesweredividedintocontrolgroup(rrf8)andobservationgroupthecontrolgrouponlyreceivedbestsupportivecaretreatment;observationgroupwastreatedwithlobaplatin3ttrg/rn2firstdays,intravenousdrip,21daysare1periodalsoreceivedbestsupportivecaretreatmentProgressinthetreatmenttothediseaseThemedianprogressionfreesurvivaltiire(PFS),qualityoflife(QX).[Results]mparedwiththecontrolg