紫杉醇联合氟尿嘧啶、亚叶酸钙治疗老年晚期胃癌.doc

紫杉醇联合氟尿嘧啶、亚叶酸钙治疗老年晚期胃癌                  作者:钟海均,应杰儿,刘碧霞,杨云山【摘要】 [目的]探讨紫杉醇联合氟尿嘧啶持续滴注加亚叶酸钙治疗老年晚期胃癌的疗效及毒副反应。[方法]32例胃癌患者应用紫杉醇135mg/m2,分第1、8天静滴,亚叶酸钙(CF)100mg/m2第1、2、3天静滴,氟尿嘧啶(5-Fu)500mg/m2第1天静滴2h,以后用5-Fu2500mg/m2泵内持续滴注,持续70h,21~28天为1个周期,至少2个周期开始评价疗效。[结果]30例患者可评价疗效,获PR12例,NC8例,PD10例,全组未见CR病例,%,;%,;%,。毒副反应主要为Ⅰ~Ⅱ度血液学毒性及消化道反应。[结论]紫杉醇联合氟尿嘧啶持续滴注加亚叶酸钙治疗老年晚期胃癌疗效肯定,患者均能耐受。特别对初治患者,值得深入研究。【关键词】 胃肿瘤   CombinationofPaclitaxel,5-FluorouracilandLeucovorin ancer    Abstract: [Purpose]binationofpaclitaxel,5-fluorouracil(5-Fu)andleucovorin(CF)ancer.[Methods]Thirty-,d1,d8;CF100mg/m2,d1~3;and5-Fu500mg/m2,intravenouslyover2honday1,followedbycontinuousintravenousinfusionatadoseof2500mg/m2for70h. Thetreatmentwasrepeatedevery21or28days,andefficacywasevaluatedaftertwocycles.[Results](PR);8,stabledisease(SD);10,progressivedisease(PD)pleteresponse(CR).Theoverallresponserate(ORR)%,%,%Ⅰ~Ⅱ.[binationof paclitaxel,5-ancer,especiallyforinitialtreatment.   Keywords:eoplasms;chemotherapy;paclitaxel;fluorou