牛磺酸对大鼠脑缺血再灌注损伤的保护作用.doc

牛磺酸对大鼠脑缺血再灌注损伤的保护作用        [07-10-0611:18:00]    编辑:studa20                             作者:成彩莲王晓娟何丽娅夏瑞明朱汉荣姚建华【关键词】 ,脑保护作用【摘要】目的 观察牛磺酸(Tau)对大鼠急性脑缺血再灌注损伤的保护作用。方法 采用大鼠急性不完全性脑缺血再灌注损伤模型,测定脑组织含水量、丙二醛(MDA)、超氧化物歧化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)的含量。结果 牛磺酸能显著对抗缺血再灌注大鼠脑组织含水量、MDA含量的升高(P<,P<)以及SOD、GSH-Px活性的降低(P<,P<)。结论 牛磺酸具有保护脑缺血再灌注性损伤的作用,机制与降低脑脂质过氧化和增强氧自由基清除酶的活性有关。     关键词 牛磺酸缺血再灌注损伤超氧化物歧化酶脑保护作用      Effectsoftaurineonacuteischemiareperfusionalbrainlesioninrats          【Abstract】ObjectiveToobservetheprotectiveeffectsoftaurineagainstacutebrainlesioninducedbyis-(MDA)andtheactivitiesofsuper-oxidedismutase(SOD)andglutathioneperoxidase(GSH-Px)inthebraintissueofmiceweremeasuredonthecere-bralischemia-reperfusionlesionmodel,moncarotidarteryligationfollow-(P<,respectively)andtheattenuationofSODandGSH-Pxactivitiesinthebraintissueofratstreatedwithacuteischemia-reperfusion(P<,respectively).ConclusionTau--fectmayberelatedtotheinhibitionoflipidperoxidationaswellastheenhancementofSODandGSH-Pxactivitives.    Keywordstaurinecerebralreperfusionlesionsuperoxidedismutaseglutathioneperoxidase