盐酸胺碘酮胶囊.doc

盐酸胺碘酮胶囊盐酸胺碘酮胶囊说明书【药品名称】通用名:盐酸胺碘酮胶囊曾用名:商品名:英文名:AmiodaroneHydrochlorideCapsules汉语拼音:YansuanAndiantongjiaonang本品化学名称为:(2-丁基-3-苯并呋喃基)[4-[2-(二乙氨基)乙氧基]-3,5-二碘苯基]甲酮盐酸盐其结构式为:OCH3HCI,HCl3OCHN3OI分子式:CHINO?HCl252922分子量:【性状】本品为胶囊剂,内容物为类白色粉末。【药理毒理】本品属III类抗心律失常药。主要电生理效应是延长各部心肌组织的动作电位及有效不应期,有利于消除折返激动。同时具有轻度非竞争性的,及,肾上腺素受体阻滞和轻度I及IV类抗心律失常药性质。减低窦房结自律性。对静息膜电位及动作电位高度无影响。对房室旁路前向传导的抑制大于逆向。由于复极过度延长,口服后心电图有QT间期延长及T波改变,可以减慢心率15~20%,使PR和Q-T间期延长10%左右。对冠状动脉及周围血管有直接扩张作用。可影响甲状腺素代谢。本品特点为半衰期长,故服药次数少,治疗指数大,抗心律失常谱广。【药代动力学】5,workingmechanism,someofthefunctionsofregulatorymeasuresdidnotformnormalization,areengagedinmass,engageinRaidersofthephenomenon,notreallysooftencaught,oftengrasping;somecrossdepartmentfunctionsandresponsibilitiesunclear,shuffledisputesovertrifles;somedepartmentscreateatmospherethickenough,onthefacadeoftheglamorousbutinternalenvironmentdirtyandmessy,pliance,,thecountyatalllevelsanddepartmentsmustattachgreatimportanceto,tocatchcatchearlysmall,targeted,takeeffectivemeasurestosolvethem,tocreatetheactualresultsofcityletpeoplelivebetter,moreharmonious,,focus,,adheretothe"tohitthecitytopromotethework,letacityforthebenefitofthepeople,thefundamentalpurposeof,fullyoptimizedtopromotetheconstructionof"eight"ofthelargerenvironment,andconstantlyimprovethequalityandextentofurbancivilizationcivilizedpeople,strivetoJuxianbuiltintoabeautifulenvironment,goodorder,qualityservice,people'。生物利用度约为50,,表观分布容积大约60L,kg,主要分布于脂肪组织及含脂肪丰富的器官。其次为心、肾、肺、肝及淋巴结。最低的是脑、甲状腺及肌肉。,与白蛋白结合,,可能与,脂蛋白结合。主要在肝内代谢消除,代谢产物为去乙基胺碘酮。(组织中摄取),长期服药半衰期(t)为13,30天。终末1/2血浆清除半衰期可达40,55天。停药后半年仍可测出血药浓度。口服后3,7小时血药浓度达峰值。约1个月可达稳态血药浓度,,。4,5天作用开始,5,7天达最大作用,有时可在1,3周才出现。停药后作用可持续8,10天,偶可持续45天。原药在尿中未能测