microRNA对肿瘤细胞自噬调控的研究进展.doc


microRNA 对肿瘤细胞自噬调控的研究进展
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李玲1,徐苗1,2,陈雪芹1,2,周桥1,2**
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(1. 四川大学华西医院病理研究室,成都 610041;
2. 四川大学华西医院病理科,成都 610041)
摘要:自噬(autophagy)是真核细胞通过溶酶体对自身亚细胞结构进行降解的生物学过程,
调控细胞生长、分化以及维持内环境稳态等生物学行为。此外,自噬在肿瘤发生与演进过程
中亦发挥重要作用,既能抑制肿瘤的早期发生,又能促进肿瘤进展,还能导致肿瘤耐药性和
治疗抵抗。微小 RNA (microRNA, miRNA)是一类调控性非编码 RNA,参与胚胎发育、肿瘤
发生等众多生理和病理过程,近年研究显示微小 RNA 也是重要的自噬调控因子。miRNA-
自噬调控紊乱可能是肿瘤及其它疾病过程中重要的分子事件,研究其机制将为阐明肿瘤等疾
病过过程的发病机制及探索新的治疗策略提供新的思路。
关键词:病理学;自噬;微小 RNA;肿瘤发生;肿瘤治疗
中图分类号:R363
Research Progresses On MicroRNAs Regulation of
Tumor Cells Autophagy
LI Ling1, XU Miao1,2, CHEN Xueqin1,2, ZHOU Qiao1,2
(1. Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu 610041;
2. Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041)
Abstract: Autophagy is a biologic process by which subcellular structures are degraded in
lysosomes in eukaryotic cells. It is involved in cell growth, differentiation and internal
environment homeostasis. Autophagy also plays important roles in tumorigenesis and progression,
as well as drug resistance. MicroRNAs are regulatory noncoding RNAs which participate in
diverse biologic and pathologic processes such as embryonic development and
microRNA-autophagy regulation may be important molecular event in
tumorigenesis and tumor progression. Thus, research in the regulatory mechanism of m