多西紫杉醇与顺钳联合化疗治疗非小细胞肺癌【关键词】多西摘要:冃的:多西紫杉醇与顺钳联合化疗治疗非小细胞肺癌的疗效及副反应。方法:我院2002年10月至2004年2月确诊的III〜IV期非小细胞肺癌45例,分成治疗组25例(多西紫杉醇75mg/in2静脉滴注,dl,顺75mg/m2静脉滴注,dl,21d-周期);对照组20例(盖诺25mg/m2,dl、d8,静脉滴注,顺钳80mg/m2,dl静脉滴注,21d一周期)。结杲:治疗组总有效率72%,对照组总有效率40%,两组有显著性差异。静脉炎发生率对照组明显高于治疗组。结论:多西紫杉醇与顺钳联合化疗治疗非小细胞肺癌是安全有效的。关键词:非小细胞肺癌;化疗;多西紫杉醇;顺钳ChemotherapywithDocetaxelandCisplatininNon-small~cel1LungCancerAbstract:Objective:binationforpatientswithnon-small-celllungcancer・Method:FromOctober2002toFebruary2004,45patientswithpathologicaldiagnosisofstageIII/IVnon-small-(treatnentandcontro1).Thetreatmentgroup(25cases)wastreatedbydocetaxelandcisplatinatthedoseof75mg/m2/donday1intravenouslyevery21days・Thecontrolgroup(20cases)wasgivennavelbine25mg/m2/donday1and8andcisplatin80mg/m2/onday1intravenouslyevery21days・Result:Theoverallresponsesforthetreatmentgroupandthecontrolgroupwere72%and40%,respectively,therewerestatisticallysignificantdifferencebetweenthetwogroups(P<).Theperipheralphlebitiswasmorepronouncedincontrolgroup().paredwiththecontrolgroup,theregimenofdocetaxelandcisplatinwaseffectiveandsafeforpatientswithnon-small-celllungcancer・Key words : Non-small-cell lungcancer;Chemotherapy;Docetaxel;Cisplatin肺癌是临床上常见恶性肿瘤。近年发病率逐年增加,非小细胞肺癌以手术为主,术后辅助放化疗,可提高疗效延长生存期。但我地区肺癌病人,就诊吋多属晚期,失去了手术时机。所以化疗在晚期非小细胞肺癌治疗中占有重耍位置。目前对非小细胞肺癌缺乏公认的有效的标准化疗方案。我们选择了多西紫杉醇加顺钳方案联合
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