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神经修复学临床治疗进展神经修复学新理念中国行—巡讲团 XXX 国际神经修复学会中国分会暨中国神经修复学会筹委会细胞或组织移植种类 1. 嗅鞘细胞或嗅粘膜 2. 施旺细胞 3. 骨髓基质(干) cell 4. 神经细胞或神经 (干/祖) 细胞 5. 脐带血(干)细胞 6. 脐带间充质 (干) 细胞 7. 巨噬细胞/造血干细胞/单核吞噬细胞/小胶质细胞 8. 神经元或神经组织来源于自体或异体细胞或组织,成人或流产胚胎细胞或组织移植途径血管内(静脉或动脉) 蛛网膜下腔脑或脊髓实质内脑室细胞治疗神经功能修复机理神经轴突再生和侧芽神经新生和血管新生神经修补或再髓鞘化神经环路或网络重建、神经重塑和神经突触重建﹡神经替代﹡神经保护(神经免疫调控和神经营养因子)﹡神经调控、激活或信号修复﹡﹡* * Trace regenerative cortical spinal tract across the injury site (14 weeks). Red: Cy3 Staining of Caspr1 shows axons with OEG myelin on both sides of the node of Ranvier (14 weeks). Green: GFP , blue: NF , red: Caspr1 . Bar: 10 μ m. 细胞治疗疾病?脊髓损伤?运动神经元病(肌萎缩侧索硬化) ?卒中(脑出血、脑梗塞) ?脑瘫?多发性硬化?帕金森病?舞蹈症?各类痴呆?多系统萎缩?颅脑损伤?各类共济失调?各类顽固性疼痛(中枢痛、颈肩腰背腿痛、软组织痛、神经病理痛、糖尿病周围神经痛等) ?肌病(肌营养不良) ?脊髓灰质炎(小儿麻痹)后遗症、脊髓灰质炎后综合征?马尾神经损伤?其他神经-精神类疾病?其它 Team Country Publication year Case number Disease Results Huang Fassas China Europe 2002 2002 2385 spinal cord injury multiple sclerosis improvement effective Huang China 2003 171 spinal cord injury improvement Park S. Korea 2005 5 spinal cord injury improvement Bang S. Korea 2005 5 stroke improvement Rabinovich Russia 2005 10 stroke safe & effective ardi Italy 2006 180 multiple sclerosis effective Sykov á Czech 2006 20 spinal cord injury improvement Yoon S. Korea 2007 35 spinal cord injury improvement io Italy 2007 2 multiple sclerosis Improvement & effective Saiz Mehta Spanish India 2008 2008 14180 multiple sclerosis spinal cord injury , ALS, cerebral palsy i mprovement safe Mazzini Italy 2008 9 amyotrophic lateral sclerosis i mprovement Huang China 2008 15 amyotrophic lateral sclerosis i mprovemen t Deda Turkey 2008 6 spinal cord injury safe & effective 近期神经修复学细胞治疗临床研究部分文章 Team Country Publication year Case number Disease Results Moviglia Argentina 2009 8 spinal cord injury improvement Pal India 2009 30 spinal cord injury safe Burt US2009 21 multiple sclerosis Effective Farge France 2009 347 multiple sclerosis effective Huang China 2009 1255 spinal cord injury, amyotrophic lateral scleros