甲基强的松龙治疗慢性阻塞性肺疾病急性加重期的临床观察.doc

甲基强的松龙治疗慢性阻塞性肺疾病急性加重期的临床观察.doc屮基强的松龙治疗慢性阻塞性肺疾病急性加重期的临床观察[摘要]目的:观察静脉用甲基强的松龙对慢性阻寒性肺疾病急性加重期治疗的临床疗效及意义。方法:将轻屮度COPD患者30例及重度C0PD患者32例均随机分为两组,分别以抗感染、祛痰、雾化、扩张支气管、控制性氧疗等作为基础治疗,治疗组加用甲基强的松龙组间分别进行疗效观察。结果:轻屮度COPD静脉甲基强的松龙治疗组疗效与对照组比较,菲异无统计学意义(P>0・05)。重度C0PD静脉甲基强的松龙治疗组疗效与对照组比较,差异冇统计学意义(P<)o结论:在抗感染、祛痰、扩张支气管等治疗基础上,短期、适量应用全身糖皮质激素对急性加重期的重度COPD患者肺功能有明显的改善作用,临床疗效明显,而对急性加重期的轻屮度COPD患者作用不明显。[关键词]甲基强的松龙;慢性阻塞性肺疾病;急性加重;FEV1%预计值;肺通气[屮图分类号]R5[文献标识码]A[文章编号]1673-7210(2010)01(c)-069- treatmentofchronicobstructivepulmonarydiseasewithacuteexacerbationDONGZebol,CAIIIongving2(*sHospitalofMingshanCounty,Mingshan625100,China;'sHospitalofAnshunCity,Anshun625100,China)[Abstract]Objective::30casesofmildtomoderateCOPDpatientsand32casesofsevereCOPDpatientswererandomlydividedintotwogroupseach,theywererespectivelygivenanti-inflainmatory,expectorant,atomization,expansionbronchus,controlledoxygentherapy,etc.,:paredwithcontrolgroup,nosignificantdiffereneeinefficacy(P>).However,significanteffectofsevereCOPDgroup(P<).Conelusion:Usingontibiotics,ashort-term,regularapplicationofsystemicglucocorticoidsinac